 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, September 1, 2001, 21(17):6706-6717
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
Viorica Pencea1, Kimberly D. Bingaman1, 2, Stanley J. Wiegand3, and Marla B. Luskin1 Departments of 1 Cell Biology and 2 Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, and 3 Regeneron Pharmaceuticals Inc., Tarrytown, New York 10591
The findings that brain-derived neurotrophic factor (BDNF) promotes in vitro the survival and/or differentiation of postnatal subventricular zone (SVZ) progenitor cells and increases in vivo the number of the newly generated neurons in the adult rostral migratory stream and olfactory bulb prompted us to investigate whether the infusion of BDNF influences the proliferation and/or differentiation of cells in other regions of the adult forebrain. We examined the distribution and phenotype of newly generated cells in the adult rat forebrain 16 d after intraventricular administration of BDNF in conjunction with the cell proliferation marker bromodeoxyuridine (BrdU) for 12 d. BDNF infusion resulted in numerous BrdU+ cells, not only in the SVZ lining the infused lateral ventricle, but moreover, in specific parenchymal structures lining the lateral and third ventricles, including the striatum and septum, as well as the thalamus and hypothalamus, in which neurogenesis had never been demonstrated previously during adulthood. In each region, newly generated cells expressed the neuronal marker microtubule-associated protein-2, or neuron-specific tubulin, identified by the antibody TuJ1. The percentage of the newly generated cells expressing TuJ1 ranged from 27 to 42%, suggesting that the adult forebrain has a more profound capacity to produce neurons than recognized previously. The extent of cell proliferation after BDNF infusion was correlated with the level of expression of full-length TrkB, the high-affinity receptor for BDNF, despite the fact that the BrdU+ cells were not themselves TrkB+. Collectively, our results demonstrate that the adult brain parenchyma may recruit and/or generate new neurons, which could replace those lost as a result of injury or disease.
Key words: brain-derived neurotrophic factor; cell proliferation; forebrain parenchyma; intraventricular infusion; postnatal neurogenesis; subventricular zone
Copyright © 2001 Society for Neuroscience 0270-6474/01/21176706-12$05.00/0
This article has been cited by other articles:
J. Jiao and D. F. Chen
Induction of Neurogenesis in Nonconventional Neurogenic Regions of the Adult Central Nervous System by Niche Astrocyte-Produced Signals
Stem Cells, May 1, 2008; 26(5): 1221 - 1230.
[Abstract] [Full Text] [PDF]
C. E. Khodr, S. M. Clark, D. L. Hurley, and C. J. Phelps
Long-Term, Homologous Prolactin, Administered through Ectopic Pituitary Grafts, Induces Hypothalamic Dopamine Neuron Differentiation in Adult Snell Dwarf Mice
Endocrinology, April 1, 2008; 149(4): 2010 - 2018.
[Abstract] [Full Text] [PDF]
K. G. Bath, N. Mandairon, D. Jing, R. Rajagopal, R. Kapoor, Z.-Y. Chen, T. Khan, C. C. Proenca, R. Kraemer, T. A. Cleland, et al.
Variant Brain-Derived Neurotrophic Factor (Val66Met) Alters Adult Olfactory Bulb Neurogenesis and Spontaneous Olfactory Discrimination
J. Neurosci., March 5, 2008; 28(10): 2383 - 2393.
[Abstract] [Full Text] [PDF]
S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
J. Neurosci., November 7, 2007; 27(45): 12156 - 12167.
[Abstract] [Full Text] [PDF]
A. Kerever, J. Schnack, D. Vellinga, N. Ichikawa, C. Moon, E. Arikawa-Hirasawa, J. T. Efird, and F. Mercier
Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor Fibroblast Growth Factor 2 from the Extracellular Milieu
Stem Cells, September 1, 2007; 25(9): 2146 - 2157.
[Abstract] [Full Text] [PDF]
C. Wang, E. Bomberg, C. Billington, A. Levine, and C. M. Kotz
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1003 - R1012.
[Abstract] [Full Text] [PDF]
W.-R. Schabitz, T. Steigleder, C. M. Cooper-Kuhn, S. Schwab, C. Sommer, A. Schneider, and H. G. Kuhn
Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis
Stroke, July 1, 2007; 38(7): 2165 - 2172.
[Abstract] [Full Text] [PDF]
S. M. Mooney and M. W. Miller
Postnatal Generation of Neurons in the Ventrobasal Nucleus of the Rat Thalamus
J. Neurosci., May 9, 2007; 27(19): 5023 - 5032.
[Abstract] [Full Text] [PDF]
K. M. Young, T. D. Merson, A. Sotthibundhu, E. J. Coulson, and P. F. Bartlett
p75 Neurotrophin Receptor Expression Defines a Population of BDNF-Responsive Neurogenic Precursor Cells
J. Neurosci., May 9, 2007; 27(19): 5146 - 5155.
[Abstract] [Full Text] [PDF]
W. San Sebastian, J. Guillen, M. Manrique, S. Belzunegui, E. Ciordia, A. Izal-Azcarate, P. Garrido-Gil, M. Vazquez-Claverie, and M. R. Luquin
Modification of the number and phenotype of striatal dopaminergic cells by carotid body graft
Brain, May 1, 2007; 130(5): 1306 - 1316.
[Abstract] [Full Text] [PDF]
T. Sasaki, K. Kitagawa, E. Omura-Matsuoka, K. Todo, Y. Terasaki, S. Sugiura, J. Hatazawa, Y. Yagita, and M. Hori
The Phosphodiesterase Inhibitor Rolipram Promotes Survival of Newborn Hippocampal Neurons After Ischemia
Stroke, May 1, 2007; 38(5): 1597 - 1605.
[Abstract] [Full Text] [PDF]
S. Jomura, M. Uy, K. Mitchell, R. Dallasen, C. J. Bode, and Y. Xu
Potential Treatment of Cerebral Global Ischemia with Oct-4+ Umbilical Cord Matrix Cells
Stem Cells, January 1, 2007; 25(1): 98 - 106.
[Abstract] [Full Text] [PDF]
D. M. de Groot, A. J. M. Coenen, A. Verhofstad, F. van Herp, and G. J. M. Martens
In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor
Mol. Endocrinol., November 1, 2006; 20(11): 2987 - 2998.
[Abstract] [Full Text] [PDF]
R. D. Bhardwaj, M. A. Curtis, K. L. Spalding, B. A. Buchholz, D. Fink, T. Bjork-Eriksson, C. Nordborg, F. H. Gage, H. Druid, P. S. Eriksson, et al.
From the Cover: Neocortical neurogenesis in humans is restricted to development
PNAS, August 15, 2006; 103(33): 12564 - 12568.
[Abstract] [Full Text] [PDF]
J. M. Van Kampen and C. B. Eckman
Dopamine D3 receptor agonist delivery to a model of Parkinson's disease restores the nigrostriatal pathway and improves locomotor behavior.
J. Neurosci., July 5, 2006; 26(27): 7272 - 7280.
[Abstract] [Full Text] [PDF]
T. Yamashita, M. Ninomiya, P. Hernandez Acosta, J. M. Garcia-Verdugo, T. Sunabori, M. Sakaguchi, K. Adachi, T. Kojima, Y. Hirota, T. Kawase, et al.
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.
J. Neurosci., June 14, 2006; 26(24): 6627 - 6636.
[Abstract] [Full Text] [PDF]
D. Reimers, A. S. Herranz, J. J. Diaz-Gil, M. V. T. Lobo, C. L. Paino, R. Alonso, M. J. Asensio, R. Gonzalo-Gobernado, and E. Bazan
Intrastriatal Infusion of Liver Growth Factor Stimulates Dopamine Terminal Sprouting and Partially Restores Motor Function in 6-Hydroxydopamine-lesioned Rats
J. Histochem. Cytochem., April 1, 2006; 54(4): 457 - 465.
[Abstract] [Full Text] [PDF]
F. Luzzati, S. De Marchis, A. Fasolo, and P. Peretto
Neurogenesis in the Caudate Nucleus of the Adult Rabbit
J. Neurosci., January 11, 2006; 26(2): 609 - 621.
[Abstract] [Full Text] [PDF]
S. Bauer and P. H. Patterson
The cell cycle-apoptosis connection revisited in the adult brain
J. Cell Biol., November 21, 2005; 171(4): 641 - 650.
[Abstract] [Full Text] [PDF]
M. V. Kokoeva, H. Yin, and J. S. Flier
Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
Science, October 28, 2005; 310(5748): 679 - 683.
[Abstract] [Full Text] [PDF]
R. L. Zhang, Z. G. Zhang, and M. Chopp
Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy
Neuroscientist, October 1, 2005; 11(5): 408 - 416.
[Abstract] [PDF]
C. Estrada and M. Murillo-Carretero
Nitric Oxide and Adult Neurogenesis in Health and Disease
Neuroscientist, August 1, 2005; 11(4): 294 - 307.
[Abstract] [PDF]
J. Lu, Y. Wu, N. Sousa, and O. F. X. Almeida
SMAD pathway mediation of BDNF and TGF{beta}2 regulation of proliferation and differentiation of hippocampal granule neurons
Development, July 15, 2005; 132(14): 3231 - 3242.
[Abstract] [Full Text] [PDF]
T. E. Kippin, S. Kapur, and D. van der Kooy
Dopamine Specifically Inhibits Forebrain Neural Stem Cell Proliferation, Suggesting a Novel Effect of Antipsychotic Drugs
J. Neurosci., June 15, 2005; 25(24): 5815 - 5823.
[Abstract] [Full Text] [PDF]
T.-W. Wang, H. Zhang, and J. M. Parent
Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway
Development, June 15, 2005; 132(12): 2721 - 2732.
[Abstract] [Full Text] [PDF]
S. Sugiura, K. Kitagawa, S. Tanaka, K. Todo, E. Omura-Matsuoka, T. Sasaki, T. Mabuchi, K. Matsushita, Y. Yagita, and M. Hori
Adenovirus-Mediated Gene Transfer of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Enhances Neurogenesis and Angiogenesis After Focal Cerebral Ischemia in Rats
Stroke, April 1, 2005; 36(4): 859 - 864.
[Abstract] [Full Text] [PDF]
A. G. Dayer, K. M. Cleaver, T. Abouantoun, and H. A. Cameron
New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors
J. Cell Biol., January 31, 2005; 168(3): 415 - 427.
[Abstract] [Full Text] [PDF]
W. Sun, A. Winseck, S. Vinsant, O.-h. Park, H. Kim, and R. W. Oppenheim
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax
J. Neurosci., December 8, 2004; 24(49): 11205 - 11213.
[Abstract] [Full Text] [PDF]
H. Frielingsdorf, K. Schwarz, P. Brundin, and P. Mohapel
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
PNAS, July 6, 2004; 101(27): 10177 - 10182.
[Abstract] [Full Text] [PDF]
B. Alvarez-Borda, B. Haripal, and F. Nottebohm
Timing of brain-derived neurotrophic factor exposure affects life expectancy of new neurons
PNAS, March 16, 2004; 101(11): 3957 - 3961.
[Abstract] [Full Text] [PDF]
K. Jin, A. L. Peel, X. O. Mao, L. Xie, B. A. Cottrell, D. C. Henshall, and D. A. Greenberg
Increased hippocampal neurogenesis in Alzheimer's disease
PNAS, January 6, 2004; 101(1): 343 - 347.
[Abstract] [Full Text] [PDF]
E. Gustafsson, O. Lindvall, and Z. Kokaia
Intraventricular Infusion of TrkB-Fc Fusion Protein Promotes Ischemia-Induced Neurogenesis in Adult Rat Dentate Gyrus
Stroke, November 1, 2003; 34(11): 2710 - 2715.
[Abstract] [Full Text] [PDF]
M. A. Packer, Y. Stasiv, A. Benraiss, E. Chmielnicki, A. Grinberg, H. Westphal, S. A. Goldman, and G. Enikolopov
Nitric oxide negatively regulates mammalian adult neurogenesis
PNAS, August 5, 2003; 100(16): 9566 - 9571.
[Abstract] [Full Text] [PDF]
J. M. Parent
Injury-Induced Neurogenesis in the Adult Mammalian Brain
Neuroscientist, August 1, 2003; 9(4): 261 - 272.
[Abstract] [PDF]
L. Nguyen, B. Malgrange, I. Breuskin, L. Bettendorff, G. Moonen, S. Belachew, and J.-M. Rigo
Autocrine/Paracrine Activation of the GABAA Receptor Inhibits the Proliferation of Neurogenic Polysialylated Neural Cell Adhesion Molecule-Positive (PSA-NCAM+) Precursor Cells from Postnatal Striatum
J. Neurosci., April 15, 2003; 23(8): 3278 - 3294.
[Abstract] [Full Text] [PDF]
Y. ZHU, K. JIN, X. O. MAO, and D. A. GREENBERG
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
FASEB J, February 1, 2003; 17(2): 186 - 193.
[Abstract] [Full Text] [PDF]
C. Vicario-Abejon, M. J. Yusta-Boyo, C. Fernandez-Moreno, and F. de Pablo
Locally Born Olfactory Bulb Stem Cells Proliferate in Response to Insulin-Related Factors and Require Endogenous Insulin-Like Growth Factor-I for Differentiation into Neurons and Glia
J. Neurosci., February 1, 2003; 23(3): 895 - 906.
[Abstract] [Full Text] [PDF]
P. Brundin
GDNF treatment in Parkinson's disease: time for controlled clinical trials?
Brain, October 1, 2002; 125(10): 2149 - 2151.
[Full Text] [PDF]
K. Jin, Y. Zhu, Y. Sun, X. O. Mao, L. Xie, and D. A. Greenberg
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
PNAS, September 3, 2002; 99(18): 11946 - 11950.
[Abstract] [Full Text] [PDF]
K. Jin, X. O. Mao, Y. Sun, L. Xie, L. Jin, E. Nishi, M. Klagsbrun, and D. A. Greenberg
Heparin-Binding Epidermal Growth Factor-Like Growth Factor: Hypoxia-Inducible Expression In Vitro and Stimulation of Neurogenesis In Vitro and In Vivo
J. Neurosci., July 1, 2002; 22(13): 5365 - 5373.
[Abstract] [Full Text] [PDF]
J. M. Parent, V. V. Valentin, and D. H. Lowenstein
Prolonged Seizures Increase Proliferating Neuroblasts in the Adult Rat Subventricular Zone-Olfactory Bulb Pathway
J. Neurosci., April 15, 2002; 22(8): 3174 - 3188.
[Abstract] [Full Text] [PDF]
S. G. Dorsey, L. L. Bambrick, R. J. Balice-Gordon, and B. K. Krueger
Failure of Brain-Derived Neurotrophic Factor-Dependent Neuron Survival in Mouse Trisomy 16
J. Neurosci., April 1, 2002; 22(7): 2571 - 2578.
[Abstract] [Full Text] [PDF]
A. Alvarez-Buylla and J. M. Garcia-Verdugo
Neurogenesis in Adult Subventricular Zone
J. Neurosci., February 1, 2002; 22(3): 629 - 634.
[Full Text] [PDF]
|
|
|
|
 |
|